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Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

《化学科学与工程前沿(英文)》 2021年 第15卷 第2期   页码 221-237 doi: 10.1007/s11705-020-1927-8

摘要: Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degradation, as well as exceptional thermal and chemical stability. Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods, property characterization to potential applications of ZIF-8. This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery. The potential risks of using ZIF-8 for drug delivery are also summarized.

关键词: zeolitic imidazolate framework-8 (ZIF-8)     synthesis methods     applications     drug delivery    

Parametric study on the mixed solvent synthesis of ZIF-8 nano- and micro-particles for CO adsorption:

Alireza Hadi, Javad Karimi-Sabet, Abolfazl Dastbaz

《化学科学与工程前沿(英文)》 2020年 第14卷 第4期   页码 579-594 doi: 10.1007/s11705-018-1770-3

摘要: The room temperature synthesis of ZIF-8 micro- and nano-particles was investigated using a mixed methanol-water solvent system. ZIF-8 particles of good quality and high crystallinity were obtained. Response surface methodology was used to determine the effect of the synthesis conditions on the ZIF-8 yield, particle size distribution, and mean particle size. The ligand/metal salt molar ratio followed by the amount of sodium formate (the deprotonating agent) and then the amount of water (i.e., the composition of the mixed solvent) respectively had the largest effects on both the ZIF-8 yield and particle size. Results showed that mixing of solvents with different strengths in producing ZIF-8 crystals is a practical method to size-controlled synthesis of ZIF-8 particles. This method is more favorable for industrial-scale ZIF-8 synthesis than using excess amounts of ligands or chemical additives (like sodium formate). In addition, ZIF-8 samples with different mean particle sizes (100, 500, and 1000 nm) were used for CO adsorption and the mid-sized ZIF-8 particles had the highest adsorption capacity.

关键词: metal organic frameworks     zeolitic imidazolate frameworks     ZIF-8     response surface methodology     Box Behnken design     CO adsorption    

用于环境催化的MoS2/ZIF-8复合材料——太阳能驱动的抗生素降解工程 Article

陈文倩, 李琳悦, 李林, 裘文慧, 唐量, 徐玲, 许科军, 吴明红

《工程(英文)》 2019年 第5卷 第4期   页码 755-767 doi: 10.1016/j.eng.2019.02.003

摘要: 在本文中,我们提供了一种MoS2/ZIF-8复合光催化剂,它可以使环丙沙星(CIP)和盐酸四环素(TC)的光催化降解率分别达到1T/2H-MoS2的1.21倍和MoS2/ZIF-8纳米复合材料的产氢率是MoS2的1.79倍。

关键词: 1T/2H-MoS2     ZIF-8     抗生素降解     光催化    

Pyrolysis transformation of ZIF-8 wrapped with polytriazine to nitrogen enriched core-shell polyhedrons

Nuoya Wang, Xinhua Huang, Lei Zhang, Jinsong Hu, Yimin Chao, Ruikun Zhao

《化学科学与工程前沿(英文)》 2021年 第15卷 第4期   页码 944-953 doi: 10.1007/s11705-020-2005-y

摘要: This work presents a simple effective strategy to synthesize -doped and shell-controlled carbon nanocages through a package baking approach. A green approach to synthesize core-shell ZIF-8@PTZ nanoparticles involves zinc contained ZIF-8 core wrapped by a N-enriched polytriazine (PTZ). Synthesized core-shell ZIF-8@PTZ nanoparticles are calcinated to further sublime zinc through PTZ shell and washed by HCl, leaving a porous carbon structure. At the meantime, hollow cavities were introduced into N-doped carbon polyhedrons via the sacrifice of ZIF-8 template (noted as ZIF-8@C/N-x). The electrochemical performance of the ZIF-8@C/N-x as supercapacitor electrode has demonstrated high energy density and specific capacitance, as well as a long-term cycleability showing 92% capacitance retention after 10000 cycles. There is a systematic correlation between micro-/meso-porosity of ZIF-8@C/N-x and their electrochemical performances.

关键词: core-shell     EDLC electrode     microporos nano polygons     nitrogen doped carbon    

Boosting the direct conversion of NHHCO electrolyte to syngas on Ag/Zn zeolitic imidazolate framework

《化学科学与工程前沿(英文)》 2023年 第17卷 第9期   页码 1196-1207 doi: 10.1007/s11705-022-2289-1

摘要: The electrochemical reduction of NH4HCO3 to syngas can bypass the high energy consumption of high-purity CO2 release and compression after the ammonia-based CO2 capture process. This technology has broad prospects in industrial applications and carbon neutrality. A zeolitic imidazolate framework-8 precursor was introduced with different Ag contents via colloid chemical synthesis. This material was carbonized at 1000 °C to obtain AgZn zeolitic imidazolate framework derived nitrogen carbon catalysts, which were used for the first time for boosting the direct conversion of NH4HCO3 electrolyte to syngas. The AgZn zeolitic imidazolate framework derived nitrogen carbon catalyst with a Ag/Zn ratio of 0.5:1 achieved the highest CO Faradaic efficiency of 52.0% with a current density of 1.15 mA·cm–2 at –0.5 V, a H2/CO ratio of 1–2 (–0.5 to –0.7 V), and a stable catalytic activity of more than 6 h. Its activity is comparable to that of the CO2-saturated NH4HCO3 electrolyte. The highly discrete Ag-Nx and Zn-Nx nodes may have combined catalytic effects in the catalysts synthesized by appropriate Ag doping and sufficient carbonization. These nodes could increase active sites of catalysts, which is conducive to the transport and adsorption of reactant CO2 and the stability of *COOH intermediate, thus can improve the selectivity and catalytic activity of CO.

关键词: Ag catalyst     zeolitic imidazolate framework     CO2 electroreduction     ammonium bicarbonate electrolyte     syngas    

Cobalt-nanoparticle catalysts derived from zeolitic imidazolate framework@MXene composites for efficient

《化学科学与工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11705-023-2378-9

摘要: In this study, we synthesize a catalyst comprising cobalt nanoparticles supported on MXene by pyrolyzing a composite in a N2 environment. Specifically, the composite comprises a bimetallic Zn/Co zeolitic imidazole framework grown in situ on the outer surface of MXene. The catalytic efficiency of the catalyst is tested for the self-coupling of 4-methoxybenzylamine to produce value-added imine, where atmospheric oxygen (1 atm) is used as the oxidant. Based on the results, the catalyst displayed impressive catalytic activity, achieving 95.4% yield of the desired imine at 383 K for 8 h. Furthermore, the catalyst showed recyclability and tolerance toward benzylamine substrates with various functional groups. The outstanding performance of the catalyst is primarily attributed to the synergetic catalytic effect between the cobalt nanoparticles and MXene support, while also benefiting from the three-dimensional porous structure. Additionally, a preliminary investigation of potential reaction mechanisms is conducted.

关键词: MXene     sacrificial template     oxidative self-coupling     Co nanoparticles     imine    

膜接触破乳——用于油包水乳液分离的超疏水ZIF-8@rGO膜 Article

顾佳慧, 瞿周, 张祥宁, 范红玮, 李春喜, Jürgen Caro, 孟洪

《工程(英文)》 2023年 第23卷 第4期   页码 73-81 doi: 10.1016/j.eng.2022.02.017

摘要: 具体制备过程分为两步,首先通过真空辅助抽滤法在聚四氟乙烯(PTFE)基底上组装ZIF-8@rGO微球(ZGS)层,再采用聚二甲基硅氧烷(PDMS)交联溶液进行固定化处理。由于ZGS表面为微纳米阶层结构,所制备的ZIF-8@rGO@PDMS/PTFE(ZGPP)膜表面展现出超疏水性特性,当表面活性剂稳定的油包水乳液接触到膜表面时,微纳结构的超疏水膜表面会引起水-油界面不平衡

关键词: 油包水乳液     破乳     油水分离     超疏水膜    

Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

null

《医学前沿(英文)》 2015年 第9卷 第1期   页码 72-76 doi: 10.1007/s11684-014-0347-x

摘要:

Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases (MMPs) secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups: group I consisted of 20 periodontally healthy subjects (controls) while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth (PPD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI). Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA (Windows version 6) software. Salivary MMP-8 levels of groups I and II were 190.91±143.89 ng/ml and 348.26±202.1 ng/ml, respectively. The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and significant correlations (for PPD, r = 0.63, P<0.001; for CAL, r = 0.54, P<0.001; for GI, r = 0.49, P<0.001; and for PI, r = 0.63, P<0.001). The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.

关键词: matrix metalloproteinase-8     chronic periodontitis     pocket probing depth     clinical attachment level     gingival index     plaque index    

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

《农业科学与工程前沿(英文)》 2019年 第6卷 第2期   页码 188-196 doi: 10.15302/J-FASE-2019253

摘要:

Microneme proteins (MICs) are important for Apicomplexan parasite invasion due to their adhesion to host cells. Several studies have indicated that MIC3 and MIC8 are important adhesion factors and potential vaccine candidates against neosporosis. In this study, we evaluated the protective efficacy of recombinant proteins and DNA vaccines of NcMIC3 and NcMIC8. BALB/c mice were immunized with rNcMIC3, rNcMIC8, pcDNA3.1-NcMIC3 and pcDNA3.1-NcMIC8 respectively, and challenged with tachyzoites. The immune responses were evaluated through cytokine, antibody measurements and the parasite burden in the mice brain tissues. Serological analysis showed that recombinant protein vaccines induced higher levels of immunoglobulin G (IgG) than other groups. The percentage of IgG1 and IgG2a in the recombinant protein groups was higher than the other groups, and with a predominance of IgG1 over IgG2a, suggesting that recombinant protein vaccines elicited a Th2-type immune response, while DNA vaccines mainly produce a Th1-type immune response. In addition, mice immunized with rNcMIC3 and rNcMIC8 a had lower parasite burden in brain tissue compared with the other groups. These results demonstrate that rNcMIC3 and rNcMIC8 could induce humoral and Th2-type immune response, leading to a considerable level of resistance against neosporosis.

关键词: NcMIC3     NcMIC8     Neospora caninum     vaccination    

青岛地铁8号线海底隧道

贺维国, 刘鹏

《工程(英文)》 2018年 第4卷 第2期   页码 167-169 doi: 10.1016/j.eng.2018.03.012

8英寸绝缘栅双极型晶体管 (IGBT) 关键技术研究 Article

刘国友,丁荣军,罗海辉

《工程(英文)》 2015年 第1卷 第3期   页码 361-366 doi: 10.15302/J-ENG-2015043

摘要:

基于8英寸绝缘栅双极型晶体管 (IGBT) 生产线的建设,重点解决了8英寸IGBT先进工艺技术、第四代高压双扩散金属氧化物半导体 (DMOS+) IGBT技术和第五代沟槽栅IGBT技术等关键技术问题,实现了高压IGBT芯片制造从6英寸到8英寸的技术突破,自主开发的1600 A/1.7 kV与1500 A/3.3 kV IGBT模块已经被成功制造并通过考核,现已应用于轨道交通牵引系统。

关键词: 绝缘栅双极型晶体管 (IGBT)     高功率密度     沟槽栅     8英寸     轨道交通    

Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

《医学前沿(英文)》 2021年 第15卷 第3期   页码 448-459 doi: 10.1007/s11684-020-0805-6

摘要: The ability of tumor cells to sustain continuous proliferation is one of the major characteristics of cancer. The activation of oncogenes and the mutation or inactivation of tumor suppressor genes ensure the rapid proliferation of tumor cells. The PI3K–Akt–mTOR axis is one of the most frequently modified signaling pathways whose activation sustains cancer growth. Unsurprisingly, it is also one of the most commonly attempted targets for cancer therapy. FK506 binding protein 8 (FKBP8) is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptotic function. We aimed to explain these contradictory aspects of FKBP8 in cancer by identifying a “switch” type regulator. We identified through immunoprecipitation–mass spectrometry-based proteomic analysis that the mitochondrial protein prohibitin 1 (PHB1) specifically interacts with FKBP8. Furthermore, the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTOR signaling pathway, whereas the FKBP8 level in the mitochondria was substantially reduced. Moreover, concomitant with these changes, the interaction between FKBP8 and mTOR substantially increased in the absence of PHB1. Collectively, our finding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular localization and mTOR regulating role.

关键词: prohibitin 1     FKBP8     mTOR     cell proliferation     cancer    

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

《医学前沿(英文)》 2022年 第16卷 第6期   页码 909-918 doi: 10.1007/s11684-021-0890-1

摘要: In patients with acute promyelocytic leukemia (APL), intracranial hemorrhage (ICH), if not identified promptly, could be fatal. It is the leading cause of failure of induction and early death. Thus, biomarkers that could promptly predict severe complications are critical. Here, cytokine differences between patients with APL with and without ICH were investigated to develop predictive models for this complication. The initial cytokine profiling using plasma samples from 39 patients and 18 healthy donors found a series of cytokines that were remarkedly different between patients with APL and healthy controls. The APL patients were subsequently divided into high and low white blood cell count groups. Results showed that tumor necrosis factor α and interleukin 8 (IL-8) were vital in distinguishing patients with APL who did or did not develop ICH. In addition, verification in 81 patients with APL demonstrated that the two cytokines were positively correlated with the cumulative incidence of ICH. Finally, in-vitro and in-vivo experimental evidence were provided to show that IL-8 influenced the migration of APL-derived NB4 cells and impaired the blood–brain barrier in PML/RARα positive blast-transplanted FVB/NJ mice. These assessments may facilitate the early warning of ICH and reduce future mortality levels in APL.

关键词: acute promyelocytic leukemia     intracranial hemorrhage     cytokines     biomarker    

IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

《医学前沿(英文)》 2022年 第16卷 第3期   页码 403-415 doi: 10.1007/s11684-021-0858-1

摘要: The morbidity and mortality of myeloproliferative neoplasms (MPNs) are primarily caused by arterial and venous complications, progression to myelofibrosis, and transformation to acute leukemia. However, identifying molecular-based biomarkers for risk stratification of patients with MPNs remains a challenge. We have previously shown that interferon regulatory factor-8 (IRF8) and IRF4 serve as tumor suppressors in myeloid cells. In this study, we evaluated the expression of IRF4 and IRF8 and the JAK2V617F mutant allele burden in patients with MPNs. Patients with decreased IRF4 expression were correlated with a more developed MPN phenotype in myelofibrosis (MF) and secondary AML (sAML) transformed from MPNs versus essential thrombocythemia (ET). Negative correlations between the JAK2V617F allele burden and the expression of IRF8 (P <0.05) and IRF4 (P<0.001) and between white blood cell (WBC) count and IRF4 expression (P <0.05) were found in ET patients. IRF8 expression was negatively correlated with the JAK2V617F allele burden (P <0.05) in polycythemia vera patients. Complete response (CR), partial response (PR), and no response (NR) were observed in 67.5%, 10%, and 22.5% of ET patients treated with hydroxyurea (HU), respectively, in 12 months. At 3 months, patients in the CR group showed high IRF4 and IRF8 expression compared with patients in the PR and NR groups. In the 12-month therapy period, low IRF4 and IRF8 expression were independently associated with the unfavorable response to HU and high WBC count. Our data indicate that the expression of IRF4 and IRF8 was associated with the MPN phenotype, which may serve as biomarkers for the response to HU in ET.

关键词: myeloproliferative neoplasms     IRF4     IRF8     hydroxyurea     essential thrombocythemia    

Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

null

《医学前沿(英文)》 2016年 第10卷 第2期   页码 212-218 doi: 10.1007/s11684-016-0438-y

摘要:

Hemophilia B is a hemorrhagic disease caused by the deficiency of clotting factor IX (FIX). Gene therapy might be the ultimate strategy for the disease. However, two main problems that should be solved in gene therapy for hemophilia B are immunity and safety. Self-complementary adeno-associated virus serotype 8 (scAAV8), a non-human primate AAV featuring low immunogenicity and high transfection efficiency in liver cells, might be a potential vector for hemophilia B gene therapy. A strong liver-specific promoter-1 (LP1) was inserted and mutant human FIX Arg338Ala was introduced into plasmid scAAV8-LP1 to develop an optimized AAV8 vector that expresses human clotting factor FIX (hFIX). The efficiency of scAAV8-LP1-hFIX administered through normal systemic injection or hydrodynamic injection was compared. A high expression was achieved using hydrodynamic injection, and the peak hFIX expression levels in the 5×1011 and 1×1011 virus genome (vg) cohorts were 31.94% and 25.02% of normal level, respectively, at 60 days post-injection. From the perspective of long-term (200 days) expression, both injection methods presented promising results with the concentration value maintained above 4% of normal plasma. The results were further verified by enzyme-linked immunosorbent assay and activated partial thromboplastin time. Our study provides a potential gene therapy method for hemophilia B.

关键词: hemophilia B     AAV8     hFIX     gene therapy    

标题 作者 时间 类型 操作

Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

期刊论文

Parametric study on the mixed solvent synthesis of ZIF-8 nano- and micro-particles for CO adsorption:

Alireza Hadi, Javad Karimi-Sabet, Abolfazl Dastbaz

期刊论文

用于环境催化的MoS2/ZIF-8复合材料——太阳能驱动的抗生素降解工程

陈文倩, 李琳悦, 李林, 裘文慧, 唐量, 徐玲, 许科军, 吴明红

期刊论文

Pyrolysis transformation of ZIF-8 wrapped with polytriazine to nitrogen enriched core-shell polyhedrons

Nuoya Wang, Xinhua Huang, Lei Zhang, Jinsong Hu, Yimin Chao, Ruikun Zhao

期刊论文

Boosting the direct conversion of NHHCO electrolyte to syngas on Ag/Zn zeolitic imidazolate framework

期刊论文

Cobalt-nanoparticle catalysts derived from zeolitic imidazolate framework@MXene composites for efficient

期刊论文

膜接触破乳——用于油包水乳液分离的超疏水ZIF-8@rGO膜

顾佳慧, 瞿周, 张祥宁, 范红玮, 李春喜, Jürgen Caro, 孟洪

期刊论文

Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis

null

期刊论文

Protective efficacy of vaccination with NcMIC3 and NcMIC8 against

Taotao ZHANG, Xiao ZHANG, Qun LIU, Jianhai XU, Jing LIU

期刊论文

青岛地铁8号线海底隧道

贺维国, 刘鹏

期刊论文

8英寸绝缘栅双极型晶体管 (IGBT) 关键技术研究

刘国友,丁荣军,罗海辉

期刊论文

Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

期刊论文

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

期刊论文

IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to

期刊论文

Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

null

期刊论文